Article

Cell type-resolved proteomics reveals intra- and intercellular signaling in Alzheimer’s disease

2026-02-04

Abstract excerpt

<h4>Summary</h4> Alzheimer’s disease (AD) arises from pathological interactions among diverse brain cell types, but cell-specific proteomic changes remain underexplored. Here, we present deep proteomic profiling of sorted or proximity-labeled brain cells from AD mouse models (5xFAD and App NL-G-F ) at multiple ages, quantifying 13,411 proteins in microglia (three subtypes), astrocytes, oligodendrocyte precursor...

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Literature Corpus work: e937094f-2ed7-5f12-aa2c-df8b36071123
DOI: 10.64898/2026.02.02.703357

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