Article

Interrogation of T Cell-Enriched Tumors Reveals Prognostic and Immunotherapeutic Implications of Polyamine Metabolism

2021-10-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The presence of cytotoxic tumor infiltrating lymphocytes (TILs) and antigen (e.g., viral, tumor neoantigens) enhances anti-tumor immunity. However, features including recruitment of tolerogenic cell types, nutrient-depletion, and the establishment of an acidic and hypoxic microenvironment diminish anti-tumor lymphocyte function. We sought to understand why the anti-tumor immun...

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Literature Corpus work: c2779942-4dba-5b21-b773-9c37c5f2d306
DOI: 10.1101/2021.10.18.21265179

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