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Article

Immuno-metabolic dendritic cell vaccine signatures associate with overall survival in vaccinated melanoma patients

8 Nov 2023

Abstract excerpt

Efficacy of cancer vaccines remains low and mechanistic understanding of antigen presenting cell function in cancer may improve vaccine design and outcomes. Here, we analyze the transcriptomic and immune-metabolic profiles of Dendritic Cells (DCs) from 35 subjects enrolled in a trial of DC vaccines in late-stage melanoma (NCT01622933). Multiple platforms identify metabolism as an important biomarker of DC...

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PMID: 37938561
DOI: 10.1038/s41467-023-42881-4

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