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Integrative Multi-Omics and Single-Cell Analyses Reveal that Polyamine Metabolic Reprogramming Shapes an Immunosuppressive Microenvironment and Identifies ZWINT as a Prognostic Biomarker and Therapeutic Target in Lung Adenocarcinoma

2026-07-14

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<title>Abstract</title> <p>Background Polyamine metabolism has been increasingly recognized as a critical regulator of tumor progression and immune modulation; however, its cellular heterogeneity and clinical relevance in lung adenocarcinoma (LUAD) remain inadequately elucidated. Methods Single-cell RNA sequencing data from LUAD (GSE207422) were utilized to characterize the cellular distribution of polyamine me...

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Literature Corpus work
448ba09d-4621-5972-bc54-292ed8516ddb
DOI
10.21203/rs.3.rs-10073785/v1
Open publication

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Integrative Multi-Omics and Single-Cell Analyses Reveal that Polyamine Metabolic Reprogramming Shapes an Immunosuppressive Microenvironment and Identifies ZWINT as a Prognostic Biomarker and Therapeutic Target in Lung AdenocarcinomaDOI 10.21203/rs.3.rs-10073785/v1
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