Article

Metabolic and Epigenomic Regulation of Th17/Treg Balance by the Polyamine Pathway

2020-01-23

Abstract excerpt

<h4>ABSTRACT</h4> Cellular metabolism can orchestrate immune cell function. We previously demonstrated that lipid biosynthesis represents one such gatekeeper to Th17 cell functional state. Utilizing Compass, a transcriptome-based algorithm for prediction of metabolic flux, we constructed a comprehensive metabolic circuitry for Th17 cell function and identified the polyamine pathway as a candidate metabolic node,...

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Literature Corpus work: fc75f0be-d267-5546-8e79-1299fbdc45f6
DOI: 10.1101/2020.01.23.911966

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