Article

Decoding molecular programs that define macrophage responses to tumor-derived cues

2026-06-09

Abstract excerpt

<h4>ABSTRACT</h4> Tumor-associated macrophages (TAMs) comprise functionally diverse states that can suppress anti-tumor immunity and promote tumor progression, yet the tumor microenvironmental cues and signaling programs that generate these states remain incompletely defined. Here, we systematically stimulate primary human monocyte-derived macrophages with a panel of cytokines and metabolites abundant in the tumo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 895aa05f-6487-5e42-930a-190de82f17ca
DOI: 10.64898/2026.06.05.730376

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Decoding molecular programs that define macrophage responses to tumor-derived cuesDOI 10.64898/2026.06.05.730376Read

Tumor-associated macrophage clusters linked to immunotherapy in a pan-cancer censusSemantic proximity Read

The epigenetic landscape of tumor-associated macrophages: orchestrating immune evasion in the tumor microenvironmentSemantic proximity Read

Deciphering the tumour immune microenvironment cell by cellSemantic proximity Read

Redefining Tumor-Associated Macrophage Subpopulations and Functions in the Tumor Microenvironment.Semantic proximity Read

Cellular and spatial continuum of TAM functional states governs immune exclusion and dictates immune checkpoint resistance in melanomaSemantic proximity Read

Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies.Semantic proximity Read

Pan-cancer tumor classification by a holistic tumor microenvironment atlasSemantic proximity Read

Functionally and metabolically divergent melanoma-associated macrophages originate from common bone-marrow precursorsSemantic proximity Read

Advanced insights on tumor-associated macrophages revealed by single-cell RNA sequencing: The intratumor heterogeneity, functional phenotypes, and cellular interactions.Semantic proximity Read

Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights tumor-promoting macrophage cells in GlioblastomaSemantic proximity Read

Single-Cell Analysis of the Pan-Cancer Immune Microenvironment and scTIME PortalSemantic proximity Read

At the Interface of Tumor-Associated Macrophages and Fibroblasts: Immune-Suppressive Networks and Emerging Exploitable TargetsSemantic proximity Read