Article

Immunogenetic metabolomics revealed key enzymes that modulate CAR-T metabolism and function

2023-03-15

Abstract excerpt

Immune evasion is a critical step of cancer progression that remains a major obstacle for current T cell-based immunotherapies. Hence, we seek to genetically reprogram T cells to exploit a common tumor-intrinsic evasion mechanism, whereby cancer cells suppress T cell function by generating a metabolically unfavorable tumor microenvironment (TME). Specifically, we use an in silico screen to identify ADA and PDK1...

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Literature Corpus work: 024f7024-5eff-59cf-b5ed-e972611cf30b
DOI: 10.1101/2023.03.14.532663

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