Back to search

Article

TCR-T Modulation and Epigenetic Reprogramming for a Personalised Therapeutic Approach in Immunotherapy

2026-02-27

Abstract excerpt

Cancer immunotherapy holds immense potential for the future of medicine within the study of cancer therapeutics; however, most therapies are undermined by T-cell exhaustion and tumor immune evasion. T-cell exhaustion is caused by chronic antigen stimulation in the tumor microenvironment (TME), leading to dysfunctional epigenetically enforced states by transcription factors such as TOX and the NR4A family. Simultan...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a01c1e08-ce48-5e8e-978f-dd340f105979
DOI
10.20944/preprints202602.1881.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
TCR-T Modulation and Epigenetic Reprogramming for a Personalised Therapeutic Approach in ImmunotherapyDOI 10.20944/preprints202602.1881.v1
Fundamentals to therapeutics: Epigenetic modulation of CD8+ T Cell exhaustion in the tumor microenvironmentSemantic proximity
Reinvigorating exhausted CD8 + cytotoxic T lymphocytes in the tumor microenvironment and current strategies in cancer immunotherapySemantic proximity
Navigating the Immune Maze: Pioneering Strategies for Un-shackling Cancer Immunotherapy ResistanceSemantic proximity
The Cancer Epigenome: Exploiting Its Vulnerabilities for Immunotherapy.Semantic proximity
T-cell immunometabolism against cancer.Semantic proximity
Intracellular K <sup>+</sup> limits T cell exhaustion and preserves antitumor functionSemantic proximity
Empowering the Potential of CAR-T Cell Immunotherapies by Epigenetic ReprogrammingSemantic proximity
T cell stemness and dysfunction in tumors are triggered by a common mechanismSemantic proximity
Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistenceSemantic proximity
Cancer cells hijack T-cell mitochondriaSemantic proximity
Phenotypic Plasticity, Non-genetic Mechanisms, and Immune Drug Resistance in Cancer.Semantic proximity
Fueling CARs: metabolic strategies to enhance CAR T-cell therapySemantic proximity
Select a neighboring publication to make it the new centre.