Article

Discovery of reactive peptide inhibitors of human papillomavirus oncoprotein E6

2023-05-25

Abstract excerpt

<h4>ABSTRACT</h4> Human papillomavirus (HPV) infections account for nearly all cervical cancer cases, which is the fourth most common cancer in women worldwide. High-risk variants, including HPV16, drive tumorigenesis in part by promoting the degradation of the tumor suppressor p53. This degradation is mediated by the HPV early protein 6 (E6), which recruits the E3 ubiquitin ligase E6AP and redirects its activity...

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Literature Corpus work: c25e055f-d4b7-5b5b-9827-b8d9a5a2e5d3
DOI: 10.1101/2023.05.25.542341

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