Article

Targeted degradation of the HPV oncoprotein E6 reduces tumor burden in cervical cancer

2024-10-17

Abstract excerpt

Human Papilloma Virus (HPV)-related cancers are a global health burden, yet there are no targeted therapies available for chronically infected patients. The HPV protein E6 is essential for HPV-mediated tumorigenesis and immune evasion, making it an attractive target for antiviral drug development. In this study, we developed an E6-targeting Proteolysis Targeting Chimera (PROTAC) that inhibits the growth of HPV(+)...

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Literature Corpus work: 263d5b84-457d-5b3a-9ade-ae4cbe4148af
DOI: 10.1101/2024.10.17.618959

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