Article

De Novo Design and Computational Validation of a High-Affinity Peptide Inhibitor Targeting the HPV E1-E2 Interface

2026-06-04

Abstract excerpt

The oncogenic progression of high-risk Human Papillomavirus (HPV) strains relies on the cooperative interaction between the E1 replicative helicase and the E2 origin-binding protein to initiate viral DNA amplification. Disrupting this protein-protein interaction represents a promising, yet clinically unrealized, therapeutic paradigm for treating established HPV infections prior to malignant transformation. This st...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2d81db56-7bbf-5176-8671-c31aa1e04bb8
DOI: 10.64898/2026.06.01.729313

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

De Novo Design and Computational Validation of a High-Affinity Peptide Inhibitor Targeting the HPV E1-E2 InterfaceDOI 10.64898/2026.06.01.729313Read

Rational Design of Selective IL-2-based Activators for CAR T Cells Using AlphaFold3 and Physics-Informed Machine LearningSemantic proximity Read

De novo design of therapeutic scFvs and multi-specific engagers from sequence aloneSemantic proximity Read

High Throughput Virtual Screening and Validation of a SARS-CoV-2 Main Protease Non-Covalent InhibitorSemantic proximity Read

High-throughput protein binder discovery by rapid in vivo selectionSemantic proximity Read

De novo protein design enables targeting of intractable oncogenic interfacesSemantic proximity Read

Computational insights and impact of combinatorial peptidomimetics on immune escape SARS-CoV-2 variants.Semantic proximity Read

Discovery of reactive peptide inhibitors of human papillomavirus oncoprotein E6Semantic proximity Read

Integrative modeling in the age of machine learning: a summary of HADDOCK strategies in CAPRI rounds 47-55Semantic proximity Read

Integrative modeling in the age of machine learning: a summary of HADDOCK strategies in CAPRI rounds 47-55Semantic proximity Read

Integrative Modeling in the Age of Machine Learning: A Summary of HADDOCK Strategies in CAPRI Rounds 47–55Semantic proximity Read

Peptide Design through Binding Interface MimicrySemantic proximity Read

EvoBind: peptide binder design with inverse folding and protein structure predictionSemantic proximity Read