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Structure Based Identification and Characterization of Flavonoids That Disrupt Human Papillomavirus-16 E6 Function

23 Dec 2013

Abstract excerpt

Expression and function of the human papillomavirus (HPV) early protein 6 (E6) is necessary for viral replication and oncogenesis in cervical cancers. HPV E6 targets the tumor suppressor protein p53 for degradation. To achieve this, "high-risk" HPV E6 proteins bind to and modify the target specificity of the ubiquitin ligase E6AP (E6 associated protein). This E6-dependent loss of p53 enables the virus to bypass...

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PMID: 24376816
DOI: 10.1371/journal.pone.0084506

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