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Structure of the p53 degradation complex from HPV16

28 Feb 2024

Abstract excerpt

Human papillomavirus (HPV) is a significant contributor to the global cancer burden, and its carcinogenic activity is facilitated in part by the HPV early protein 6 (E6), which interacts with the E3-ligase E6AP, also known as UBE3A, to promote degradation of the tumor suppressor, p53. In this study, we present a single-particle cryoEM structure of the full-length E6AP protein in complex with HPV16 E6 (16E6) and...

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PMID: 38418456
DOI: 10.1038/s41467-024-45920-w

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