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Article

Identification and Characterization of Small Molecule Human Papillomavirus E6 Inhibitors

22 May 2014

Abstract excerpt

Cervical cancer is the sixth most common cancer in women worldwide and the leading cause of women's death in developing countries. Nearly all cervical cancers are associated with infection of the human papillomavirus (HPV). This sexually transmitted pathogen disrupts the cell cycle via two oncoproteins: E6 and E7. Cells respond to E7-mediated degradation of pRB by upregulating the p53 tumor suppressor pathway....

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PMID: 24854633
DOI: 10.1021/cb500229d

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