Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Production of functional, stable, unmutated recombinant human papillomavirus E6 oncoprotein: implications for HPV-tumor diagnosis and therapy.

Journal of translational medicine - 28 Jul 2016

Illiano Elena, Demurtas Olivia Costantina, Massa Silvia, Di Bonito Paola, Consalvi Valerio, Chiaraluce Roberta, Zanotto Carlo, De Giuli Morghen Carlo, Radaelli Antonia, Venuti Aldo, Franconi Rosella

Abstract excerpt

BACKGROUND: High-risk human papillomaviruses (HR-HPVs) types 16 and 18 are the main etiological agents of cervical cancer, with more than 550,000 new cases each year worldwide. HPVs are also associated with other ano-genital and head-and-neck tumors. The HR-HPV E6 and E7 oncoproteins are responsible for onset and maintenance of the cell transformation state, and they represent appropriate targets for development...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Circular Dichroism
Share to Detergents

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunity, Humoral

Share to Molecular Chaperones

Share to Oncogene Proteins, Viral

Share to Protein Denaturation

Share to Proteolysis

Share to Solubility

Source

Open in PubMed Open full text

Identifiers

PMID: 27465494
DOI: 10.1186/s12967-016-0978-6
PMCID: PMC4963926

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Production of functional, stable, unmutated recombinant human papillomavirus E6 oncoprotein: implications for HPV-tumor diagnosis and therapy.PMID 27465494Read ↗

Covalent Inhibition of the Human Papillomavirus Type 16 E6 Protein Restores p53 and Suppresses HPV-Driven TumorigenesisSemantic proximity Read ↗

Targeting the Human Papillomavirus 16 E6 Oncoprotein with AntibodiesSemantic proximity Read ↗

Novel Functions of the Human Papillomavirus E6 OncoproteinsSemantic proximity Read ↗

Isolation and functional analysis of five HPVE6 variants with respect to p53 degradation.Semantic proximity Read ↗

Structure of the p53 degradation complex from HPV16Semantic proximity Read ↗

p53 degradation activity, expression, and subcellular localization of E6 proteins from 29 human papillomavirus genotypes.Semantic proximity Read ↗

The E6 variant proteins E6I-E6IV of human papillomavirus 16: expression in cell free systems and bacteria and study of their interaction with p53.Semantic proximity Read ↗

Structural and Functional Analysis of E6 Oncoprotein: Insights in the Molecular Pathways of Human Papillomavirus-Mediated PathogenesisSemantic proximity Read ↗

Targeted degradation of the HPV oncoprotein E6 reduces tumor burden in cervical cancerSemantic proximity Read ↗

Solution structure analysis of the HPV16 E6 oncoprotein reveals a self-association mechanism required for E6-mediated degradation of p53.Semantic proximity Read ↗

Structure of High-Risk Papillomavirus 31 E6 Oncogenic Protein and Characterization of E6/E6AP/p53 Complex FormationSemantic proximity Read ↗

Cellular binding partners of the human papillomavirus E6 proteinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.