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Article

Intracellular Analysis of the Interaction between the Human Papillomavirus Type 16 E6 Oncoprotein and Inhibitory Peptides.

PloS one - 1 Jan 2015

Stutz Christina, Reinz Eileen, Honegger Anja, Bulkescher Julia, Schweizer Johannes, Zanier Katia, Travé Gilles, Lohrey Claudia, Hoppe-Seyler Karin, Hoppe-Seyler Felix

Abstract excerpt

Oncogenic types of human papillomaviruses (HPVs) cause cervical cancer and other malignancies in humans. The HPV E6 oncoprotein is considered to be an attractive therapeutic target since its inhibition can lead to the apoptotic cell death of HPV-positive cancer cells. The HPV type 16 (HPV16) E6-binding peptide pep11, and variants thereof, induce cell death specifically in HPV16-positive cancer cells. Although...

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Identifiers

PMID: 26151636
DOI: 10.1371/journal.pone.0132339
PMCID: PMC4495056

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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