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Article

Discovery of reactive peptide inhibitors of human papillomavirus oncoprotein E6

1 Jan 2023

Abstract excerpt

Human papillomavirus (HPV) infections account for nearly all cervical cancer cases, which is the fourth most common cancer in women worldwide. High-risk variants, including HPV16, drive tumorigenesis in part by promoting the degradation of the tumor suppressor p53. This degradation is mediated by the HPV early protein 6 (E6), which recruits the E3 ubiquitin ligase E6AP and redirects its activity towards...

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PMID: 38020382
DOI: 10.1039/d3sc02782a

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