Article

Covalent Inhibition of the Human Papillomavirus Type 16 E6 Protein Restores p53 and Suppresses HPV-Driven Tumorigenesis

2025-08-28

Abstract excerpt

<h4>SUMMARY</h4> High-risk human papillomavirus (HPV) infections are the etiology of approximately 5% of all cancers worldwide, including cervical, anal, and oropharyngeal malignancies. HPV E6 is a multifunctional oncoprotein that drives tumorigenesis and is best known for bridging the ubiquitin ligase E6AP (UBE3A) and p53 into a complex that leads to proteasome mediated destruction of p53. We developed small mol...

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Identifiers and source

Literature Corpus work: 05044926-9337-53f6-8155-38a92d821ad1
DOI: 10.1101/2025.08.24.671874

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