Article

A conserved amino acid in the C-terminus of HPV E7 mediates binding to PTPN14 and repression of epithelial differentiation

2020-05-23

Abstract excerpt

<h4>ABSTRACT</h4> The human papillomavirus (HPV) E7 oncoprotein is a primary driver of HPV-mediated carcinogenesis. The E7 proteins from diverse HPV bind to the host cellular non-receptor protein tyrosine phosphatase type 14 (PTPN14) and direct it for degradation through the activity of the E7-associated host E3 ubiquitin ligase UBR4. Herein we show that a highly conserved arginine residue in the C-terminal domai...

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Literature Corpus work: 24ee022b-3110-5640-904c-ca364fbf3395
DOI: 10.1101/2020.05.22.111740

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