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Increased ACTL6A Occupancy Within mSWI/SNF Chromatin Remodelers Drives Human Squamous Cell Carcinoma

2021-03-22

Abstract excerpt

<h4>Summary</h4> Mammalian SWI/SNF (BAF) chromatin remodelers play dosage-sensitive roles in many human malignancies and neurologic disorders. The gene encoding the BAF subunit, ACTL6A, is amplified at an early stage in the development of squamous cell carcinomas (SCCs), but its oncogenic role remains unclear. Here we demonstrate that ACTL6A overexpression leads to its stoichiometric assembly into BAF complexes a...

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Literature Corpus work
c20607c8-9f21-5bdb-aa44-ca9d37658b53
DOI
10.1101/2021.03.22.435873
Open publication

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Increased ACTL6A Occupancy Within mSWI/SNF Chromatin Remodelers Drives Human Squamous Cell CarcinomaDOI 10.1101/2021.03.22.435873
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