Article

ASCL1 interacts with the mSWI/SNF at distal regulatory elements to regulate neural differentiation

2022-10-09

Abstract excerpt

<h4> A bstract </h4> Pioneer transcription factors are thought to play pivotal roles in developmental processes by binding nucleosomal DNA to activate gene expression. The role of neurogenic pioneer factor ASCL1 in shaping chromatin landscape in human neurogenesis remains unclear. Here we show that ASCL1 acts as a pioneer transcription factor in a transient population of progenitors. Using an in vitro ASCL1 kn...

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Literature Corpus work: 06bac943-bb5d-53f0-9861-7cc80d453ad4
DOI: 10.1101/2022.10.09.510609

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