Article

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer’s disease

2017-02-26

Abstract excerpt

A genome-wide survival analysis of 14,406 Alzheimer’s disease (AD) cases and 25,849 controls identified eight previously reported AD risk loci and fourteen novel loci associated with age at onset. LD score regression of 220 cell types implicated regulation of myeloid gene expression in AD risk. In particular, the minor allele of rs1057233 (G), within the previously reported CELF1 AD risk locus, showed association...

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Literature Corpus work: c1c84fc2-72fd-5ec8-b694-a1a688f1abff
DOI: 10.1101/110957

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