Article
A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease.
Nature neuroscience - 1 Aug 2017
Huang Kuan-Lin, Marcora Edoardo, Pimenova Anna A, Di Narzo Antonio F, Kapoor Manav, Jin Sheng Chih, Harari Oscar, Bertelsen Sarah, Fairfax Benjamin P, Czajkowski Jake, Chouraki Vincent, Grenier-Boley Benjamin, Bellenguez Céline, Deming Yuetiva, McKenzie Andrew, Raj Towfique, Renton Alan E, Budde John, Smith Albert, Fitzpatrick Annette, Bis Joshua C, DeStefano Anita, Adams Hieab H H, Ikram M Arfan, van der Lee Sven, Del-Aguila Jorge L, Fernandez Maria Victoria, Ibañez Laura, Sims Rebecca, Escott-Price Valentina, Mayeux Richard, Haines Jonathan L, Farrer Lindsay A, Pericak-Vance Margaret A, Lambert Jean Charles, van Duijn Cornelia, Launer Lenore, Seshadri Sudha, Williams Julie, Amouyel Philippe, Schellenberg Gerard D, Zhang Bin, Borecki Ingrid, Kauwe John S K, Cruchaga Carlos, Hao Ke, Goate Alison M
Abstract excerpt
A genome-wide survival analysis of 14,406 Alzheimer's disease (AD) cases and 25,849 controls identified eight previously reported AD risk loci and 14 novel loci associated with age at onset. Linkage disequilibrium score regression of 220 cell types implicated the regulation of myeloid gene expression in AD risk. The minor allele of rs1057233 (G), within the previously reported CELF1 AD risk locus, showed...
Read the complete abstract on PubMed