Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modest changes in Spi1 dosage reveal the potential for altered microglial function as seen in Alzheimer's disease.

Scientific reports - 22 Jul 2021

Jones Ruth E, Andrews Robert, Holmans Peter, Hill Matthew, Taylor Philip R

Abstract excerpt

Genetic association studies have identified multiple variants at the SPI1 locus that modify risk and age of onset for Alzheimer's Disease (AD). Reports linking risk variants to gene expression suggest that variants denoting higher SPI1 expression are likely to have an earlier AD onset, and several other AD risk genes contain PU.1 binding sites in the promoter region. Overall, this suggests the level of SPI1 may...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Dosage
Share to Gene Regulatory Networks

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferons

Share to Microglia

Share to Primary Cell Culture

Share to Proto-Oncogene Proteins

Share to Sequence Analysis, RNA

Share to Trans-Activators

Source

Open in PubMed Open full text

Identifiers

PMID: 34294785
DOI: 10.1038/s41598-021-94324-z
PMCID: PMC8298495

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modest changes in Spi1 dosage reveal the potential for altered microglial function as seen in Alzheimer's disease.PMID 34294785Read ↗

Modest changes in <i>Spi1</i> dosage reveal the potential for altered microglial function as seen in Alzheimer’s diseaseSemantic proximity Read ↗

Alzheimer's-associated PU.1 expression levels regulate microglial inflammatory responseSemantic proximity Read ↗

Effects of SPI1-mediated transcriptome remodeling on Alzheimer's disease-related phenotypes in mouse models of Aβ amyloidosis.Semantic proximity Read ↗

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer’s diseaseSemantic proximity Read ↗

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease.Semantic proximity Read ↗

Association of SPI1 Haplotypes with Altered SPI1 Gene Expression and Alzheimer's Disease Risk.Semantic proximity Read ↗

A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammationSemantic proximity Read ↗

Effects of the spi1a gene on Alzheimer's disease-related phenotypes in a zebrafish modelSemantic proximity Read ↗

Genetic variability associated with <i>OAS1</i> expression in myeloid cells increases the risk of Alzheimer’s disease and severe COVID-19 outcomesSemantic proximity Read ↗

High throughput identification of genetic regulators of microglial inflammatory processes in Alzheimer’s diseaseSemantic proximity Read ↗

Transcription factor Sp1 dysregulation in Alzheimer's diseaseSemantic proximity Read ↗

A common 19 bp APOE enhancer deletion is protective against Alzheimer's disease in African Americans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.