Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of SPI1 Haplotypes with Altered SPI1 Gene Expression and Alzheimer's Disease Risk.

Journal of Alzheimer's disease : JAD - 1 Jan 2022

Cao Han, Zhou Xiaopu, Chen Yu, Ip Fanny C F, Chen Yuewen, Lai Nicole C H, Lo Ronnie M N, Tong Estella P S, Mok Vincent C T, Kwok Timothy C Y, Fu Amy K Y, Ip Nancy Y

Abstract excerpt

BACKGROUND: Genetic studies reveal that single-nucleotide polymorphisms (SNPs) of SPI1 are associated with Alzheimer's disease (AD), while their effects in the Chinese population remain unclear. OBJECTIVE: We aimed to examine the AD-association of SPI1 SNPs in the Chinese population and investigate the underlying mechanisms of these SNPs in modulating AD risk. METHODS: We conducted a genetic analysis of three...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to China

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression

Share to Genetic Predisposition to Disease

Share to Haplotypes

Share to Polymorphism, Single Nucleotide

Share to Proto-Oncogene Proteins

Share to Trans-Activators

Source

Open in PubMed Open full text

Identifiers

PMID: 35253752
DOI: 10.3233/JAD-215311
PMCID: PMC9108557

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of SPI1 Haplotypes with Altered SPI1 Gene Expression and Alzheimer's Disease Risk.PMID 35253752Read ↗

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer’s diseaseSemantic proximity Read ↗

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease.Semantic proximity Read ↗

Effects of SPI1-mediated transcriptome remodeling on Alzheimer's disease-related phenotypes in mouse models of Aβ amyloidosis.Semantic proximity Read ↗

Genetic risk for Alzheimer's disease is concentrated in specific macrophage and microglial transcriptional networks.Semantic proximity Read ↗

Effects of the spi1a gene on Alzheimer's disease-related phenotypes in a zebrafish modelSemantic proximity Read ↗

Transethnic analysis identifies SORL1 variants and haplotypes protective against Alzheimer's disease.Semantic proximity Read ↗

Modest changes in <i>Spi1</i> dosage reveal the potential for altered microglial function as seen in Alzheimer’s diseaseSemantic proximity Read ↗

Modest changes in Spi1 dosage reveal the potential for altered microglial function as seen in Alzheimer's disease.Semantic proximity Read ↗

A <i>multiple-causal-gene-cluster</i> model underlying GWAS signals of Alzheimer’s diseaseSemantic proximity Read ↗

Coexistence of Multiple Functional Variants and Genes Underlies Genetic Risk Locus 11p11.2 of Alzheimer's Disease.Semantic proximity Read ↗

A common 19 bp APOE enhancer deletion is protective against Alzheimer's disease in African Americans.Semantic proximity Read ↗

The impact of increasing levels of blood C-reactive protein on the inflammatory loci SPI1 and CD33 in Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.