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Article

Alzheimer's-associated PU.1 expression levels regulate microglial inflammatory response

8 Dec 2020

Abstract excerpt

More than forty loci contribute to genetic risk for Alzheimer's disease (AD). These risk alleles are enriched in myeloid cell enhancers suggesting that microglia, the brain-resident macrophages, contribute to AD risk. We have previously identified SPI1/PU.1, a master regulator of myeloid cell development in the brain and periphery, as a genetic risk factor for AD. Higher expression of SPI1 is associated with...

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PMID: 33301878
DOI: 10.1016/j.nbd.2020.105217

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