Article

Modest changes in <i>Spi1</i> dosage reveal the potential for altered microglial function as seen in Alzheimer’s disease

2021-02-13

Abstract excerpt

Genetic association studies have identified multiple variants at the SPI1 locus that modify risk and age of onset for Alzheimer’s Disease (AD). Reports linking risk variants to gene expression suggest that variants denoting higher SPI1 expression are likely to have an earlier AD onset, and several other AD risk genes contain PU.1 binding sites in the promoter region. Overall, this suggests altered levels of SPi...

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Literature Corpus work: 214517e9-2667-501c-b1c3-e5cce2a63027
DOI: 10.1101/2021.02.12.430903

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