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USP14 Haploinsufficiency Ameliorates Alzheimer’s Disease-Like Pathology in APP/PS1 Mice

2020-09-08

Abstract excerpt

<h4>Background: </h4> Alzheimer's disease (AD) is the most common cause of dementia; its main pathological features are neurofibrillary tangles (NFTs) consisting of hyperphosphorylated microtubule-associated protein (Tau) in the cell and extracellular beta-amyloid protein (Aβ)-based senile plaques (SP). The ubiquitin-proteasome system (UPS) is the main pathway for protein degradation in cells. Proteasome malfuncti...

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Literature Corpus work
c1bdd307-be82-59f9-80d8-e5e8232ad650
DOI
10.21203/rs.3.rs-68805/v1
Open publication

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USP14 Haploinsufficiency Ameliorates Alzheimer’s Disease-Like Pathology in APP/PS1 MiceDOI 10.21203/rs.3.rs-68805/v1
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