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Usp14 deficiency removes α-synuclein by regulating S100A8/A9 in Parkinson’s disease

23 May 2024

Abstract excerpt

Abstract Ubiquitin-proteasome system dysfunction triggers α-synuclein aggregation, a hallmark of neurodegenerative diseases, such as Parkinson’s disease (PD). However, the crosstalk between deubiquitinating enzyme (DUBs) and α-synuclein pathology remains unclear. In this study, we observed a decrease in the level of ubiquitin-specific protease 14 (USP14), a DUB, in the cerebrospinal fluid (CSF) of PD patients,...

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PMID: 38780644
DOI: 10.1007/s00018-024-05246-8

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