USP14 haploinsufficiency ameliorates Alzheimer’s disease-like pathology in APP/PS1 mice

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Alzheimer's disease (AD) is the most common cause of dementia; its main pathological features are neurofibrillary tangles (NFTs) consisting of hyperphosphorylated microtubule-associated protein (Tau) in the cell and extracellular beta-amyloid protein (Aβ)-based senile plaques (SP). The ubiquitin-proteasome system (UPS) is the main pathway for protein degradation...

Topics

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• Alzheimer's disease research and treatments
• Amyloid beta-Peptides
• Apolipoproteins E
• Learning
• Oxidative Stress
• Proteasome Endopeptidase Complex
• Protein Processing, Post-Translational
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

8de1cabb-7e83-551c-b32e-8179a6d1ed82

DOI

10.21203/rs.3.rs-84968/v1