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Article

USP14 as a Therapeutic Target Against Neurodegeneration: A Rat Brain Perspective

31 Jul 2020

Abstract excerpt

In the recent past, many of the deubiquitinases (DUB) were found to modulate mitochondrial clearance or mitophagy and thus they are currently projected as therapeutic targets against neurodegeneration. Among these DUBs, USP14 stands at a distinctive juncture, since it can influence both proteasome complex activity and autophagy process. USP14 interference can enhance mitochondrial clearance and thus can protect...

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PMID: 32850842
DOI: 10.3389/fcell.2020.00727

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