Article

USP14 regulates pS129 α-synuclein levels and oxidative stress in human SH-SY5Y dopaminergic cells

2024-05-09

Abstract excerpt

Ubiquitin specific protease-14 (USP14) is critical for controlling protein homeostasis disturbed in human disorders like Parkinsońs disease (PD). Here we investigated the role of USP14 in regulating proteasome and autophagy pathways, and their influence on α-synuclein (α-syn) degradation. Data showed that α-syn and phosphorylated serine129 α-syn (pS129 α-syn) were elevated in USP14 gene-deleted SH-SY5Y dopaminerg...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a26b89a5-6fd9-5c63-8c10-98a705378f85
DOI: 10.1101/2024.05.09.592905

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

USP14 regulates pS129 α-synuclein levels and oxidative stress in human SH-SY5Y dopaminergic cellsDOI 10.1101/2024.05.09.592905Read

USP14 is crucial for proteostasis regulation and α-synuclein degradation in human SH-SY5Y dopaminergic cellsSemantic proximity Read

Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson’s disease mouse modelSemantic proximity Read

Usp14 deficiency removes α-synuclein by regulating S100A8/A9 in Parkinson’s diseaseSemantic proximity Read

USP14 inhibition enhances Parkin-independent mitophagy in iNeuronsSemantic proximity Read

α-Synuclein Decreases the Abundance of Proteasome Subunits and Alters Ubiquitin Conjugates in Yeast.Semantic proximity Read

USP30 inhibition induces mitophagy and reduces oxidative stress in parkin-deficient human neuronsSemantic proximity Read

Molecular Symphony of Mitophagy: Ubiquitin‐Specific Protease‐30 as a Maestro for Precision Management of Neurodegenerative DiseasesSemantic proximity Read

Enhanced mTORC1 signaling and Protein Synthesis in Parkinson’s Disease Pathogenesis Disease PathogenesisSemantic proximity Read

Ser129 Phosphorylation Paradox: Non-phosphorylated α-Synuclein Drives Parkinson’s Disease-like Pathogenesis <i>in Vivo</i>Semantic proximity Read

USP30 inhibition induces mitophagy and reduces oxidative stress in parkin-deficient and CCCP-stressed human iPSC-derived neuronsSemantic proximity Read

Inhibition of de novo ceramide synthesis mitigates alpha-synuclein pathology and restores cognitive function in a Parkinson's disease mouse modelSemantic proximity Read

Polymorphic USP8 allele promotes Parkinson's disease by inducing the accumulation of α-synuclein through deubiquitination.Semantic proximity Read