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Article

Protein quality control in Alzheimer's disease by the ubiquitin proteasome system.

Progress in neurobiology - 1 Dec 2004

de Vrij F M S, Fischer D F, van Leeuwen F W, Hol E M

Abstract excerpt

The ubiquitin proteasome system (UPS) is the major protein quality control system in eukaryotic cells. Many neurodegenerative diseases are characterized by aggregates and inclusions of aberrant proteins, implying a sub-optimal functioning or defective UPS. The last few years have seen increasing evidence for the involvement of the UPS in neurodegenerative disorders, including Alzheimer's disease (AD). Notably,...

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PMID: 15582222
DOI: 10.1016/j.pneurobio.2004.10.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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