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USP14 inhibition enhances Parkin-independent mitophagy in iNeurons

31 Oct 2024

Abstract excerpt

Loss of proteostasis is well documented during physiological aging and depends on the progressive decline in the activity of two major degradative mechanisms: the ubiquitin-proteasome system (UPS) and the autophagy-lysosomal pathway. This decline in proteostasis is exacerbated in age-associated neurodegenerative diseases, such as Parkinson's Disease (PD). In PD, patients develop an accumulation of aggregated...

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Share to Autophagy in Disease and Therapy
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PMID: 39486496
DOI: 10.1016/j.phrs.2024.107484

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