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Article

The Ubiquitin-Proteasome System in Neurodegeneration

18 Jan 2014

Abstract excerpt

SIGNIFICANCE: Impairment of the ubiquitin-proteasome system (UPS) has been implicated in the pathogenesis of a wide variety of neurodegenerative disorders, including Alzheimer's, Parkinson's, and Huntington's diseases. The most significant risk factor for the development of these disorders is aging, which is associated with a progressive decline in UPS activity and the accumulation of oxidatively modified...

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PMID: 24437518
DOI: 10.1089/ars.2013.5802

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