The ubiquitin‐proteasome system in Alzheimer's disease

Abstract excerpt

Introduction Biology of the UPS The involvement of the UPS in AD pathogenesis The UPS as a link between Aβ and tau interaction Conclusions Abstract Accumulation of proteins is a recurring event in many neurodegenerative diseases, including Alzheimer's disease (AD).Evidence has suggested that protein accumulation may result from a dysfunction in the ubiquitin proteasome system (UPS). Indeed, there is clear genetic...

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