Article
Regulation of INF2-mediated actin polymerization through site-specific lysine acetylation of actin itself.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 2020
A Mu, Fung Tak Shun, Francomacaro Lisa M, Huynh Thao, Kotila Tommi, Svindrych Zdenek, Higgs Henry N
Abstract excerpt
INF2 is a formin protein that accelerates actin polymerization. A common mechanism for formin regulation is autoinhibition, through interaction between the N-terminal diaphanous inhibitory domain (DID) and C-terminal diaphanous autoregulatory domain (DAD). We recently showed that INF2 uses a variant of this mechanism that we term "facilitated autoinhibition," whereby a complex consisting of cyclase-associated...
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