Article

A complex containing lysine-acetylated actin inhibits the formin INF2

2018-12-31

Abstract excerpt

INF2 is a member of the formin family of actin assembly factors. Dominant mis-sense mutations in INF2 link to two diseases: focal segmental glomerulosclerosis (FSGS), a kidney disease; and Charcot-Marie-Tooth disease (CMTD), a neuropathy. All disease mutations map to the autoinhibitory Diaphanous Inhibitory Domain (DID). Curiously, purified INF2 is not autoinhibited, suggesting the existence of additional cellular...

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Literature Corpus work: 767b4848-6e3e-5820-baf4-f8992f0abb40
DOI: 10.1101/509133

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