Article
FSGS-Causing INF2 Mutation Impairs Cleaved INF2 N-Fragment Functions in Podocytes.
Journal of the American Society of Nephrology : JASN - 1 Feb 2020
Subramanian Balajikarthick, Chun Justin, Perez-Gill Chandra, Yan Paul, Stillman Isaac E, Higgs Henry N, Alper Seth L, Schlöndorff Johannes S, Pollak Martin R
Abstract excerpt
BACKGROUND: Mutations in the gene encoding inverted formin-2 (INF2), a member of the formin family of actin regulatory proteins, are among the most common causes of autosomal dominant FSGS. INF2 is regulated by interaction between its N-terminal diaphanous inhibitory domain (DID) and its C-terminal diaphanous autoregulatory domain (DAD). INF2 also modulates activity of other formins, such as the mDIA subfamily,...
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