Article
INF2 is an endoplasmic reticulum-associated formin protein.
Journal of cell science - 1 May 2009
Chhabra Ekta Seth, Ramabhadran Vinay, Gerber Scott A, Higgs Henry N
Abstract excerpt
In addition to its ability to accelerate filament assembly, which is common to formins, INF2 is a formin protein with the unique biochemical ability to accelerate actin filament depolymerization. The depolymerization activity of INF2 requires its actin monomer-binding WASP homology 2 (WH2) motif. In this study, we show that INF2 is peripherally bound to the cytoplasmic face of the endoplasmic reticulum (ER) in...
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