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Human Kidney Disease-causing INF2 Mutations Perturb Rho/Dia Signaling in the Glomerulus

17 Nov 2014

Abstract excerpt

Mutations in Inverted Formin 2 (INF2), a diaphanous formin family protein that regulates actin cytoskeleton dynamics, cause focal segmental glomerulosclerosis (FSGS) and Charcot-Marie-Tooth Disease (CMT) in humans. In addition to directly remodeling actin filaments in vitro, we have shown that INF2 regulates intracellular actin dynamics and actin dependent cellular behavior by opposing Rhoa/Dia signaling. As a...

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PMID: 26086034
DOI: 10.1016/j.ebiom.2014.11.009

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Human Kidney Disease-causing INF2 Mutations Perturb Rho/Dia Signaling in the GlomerulusPMID 26086034Read ↗

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