Article

Proteolytic program-dependent functions are impaired in INF2-mediated focal segmental glomerulosclerosis

2019-01-26

Abstract excerpt

Regulation of the actin cytoskeleton is critical for normal glomerular podocyte structure and function. Altered regulation of the podocyte cytoskeleton can lead to proteinuria, reduced kidney filtration function and focal segmental glomerulosclerosis (FSGS). Mutations in inverted formin 2 (INF2), a member of the formin family of actin regulatory proteins, are the most common cause of autosomal dominant FSGS. INF2...

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Literature Corpus work: 01e46cc6-5f1d-59e7-b98f-a514c0e0a337
DOI: 10.1101/530642

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