Article

In vitro reconstitution demonstrates the amyloid-beta mediated myelin membrane deformation

2021-08-14

Abstract excerpt

<h4>ABSTRACT</h4> Amyloid-beta (Aβ) aggregation mediated neuronal membrane deformation, although poorly understood, is implicated in Alzheimer’s Disease (AD). Particularly, whether Aβ aggregation can induce neuronal demyelination remains unknown. Here we show that Aβ-40 binds and induces extensive tubulation in the myelin membrane in vitro. The binding of Aβ-40 depends predominantly on the lipid packing defect de...

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Literature Corpus work: c19926ae-323a-5dd9-b1fb-9c64c56adbe8
DOI: 10.1101/2021.08.13.456302

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