A Nanoscale Model System for the Human Myelin Sheath

Abstract excerpt

Here, we for the first time establish nanodiscs with the challenging lipid composition of myelin of the peripheral or central nervous systems, respectively (PNS and CNS, both containing >40% cholesterol, which so far has been thought to be detrimental for nanodisc formation).Thus, we prove that more complex lipid model membrane systems are in general accessible through nanodiscs and can study protein-lipid in...

Topics

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• Genetic and Kidney Cyst Diseases
• Lipid Bilayers
• Molecular Dynamics Simulation
• Mutation
• Phosphatidylglycerols
• Protein Binding
• Protein Conformation, alpha-Helical
• Water

Identifiers and source

Literature Corpus work

64aa29c7-7a2a-5b78-bb65-77e4ae85f875

DOI

10.26434/chemrxiv.14687151.v2