Article

Structural dissection of the first events following membrane binding of the islet amyloid polypeptide

2021-12-14

Abstract excerpt

<h4>ABSTRACT</h4> Amyloid forming proteins are involved in many pathologies and often belong to the class of intrinsically disordered proteins. One of these proteins is the islet amyloid polypeptide (IAPP), which is the main constituent of the amyloid fibrils found in the pancreas of type 2 diabetes patients. The molecular mechanism of IAPP-induced cell death is not yet understood, however it is known that cell m...

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Literature Corpus work: a3ce09dc-04d0-5703-8776-a230ac93debd
DOI: 10.1101/2021.12.14.472560

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