Article

The concentric β-barrel hypothesis for amyloids: Models of soluble and transmembrane amyloid-β42 oligomers and channels composed of identical subunits and GM1 gangliosides

2026-03-23

Abstract excerpt

Soluble oligomers and transmembrane channels formed by the 42-residue variant of amyloid beta (Aβ42) play key roles in Alzheimer’s disease. Unfortunately, detailed structures of these assemblies have not been determined. Our group addresses this problem by developing atomic scale models. Previously we proposed that both soluble Aβ42 oligomers and transmembrane channels have symmetric concentric β-barrel structures...

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Literature Corpus work: a1f30a38-6215-5e27-893f-6d85dcd9aeb1
DOI: 10.64898/2026.03.19.711324

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