Article

Chaperone-driven entropic separation of amyloid nanofilament bundles

2023-05-24

Abstract excerpt

The disassembly of misfolded protein aggregates is a requirement for the proper functioning of cells. It has implications in multiple neuropathologies, such as Alzheimer’s and Parkinson’s diseases. The active unbundling of fibrillar aggregates has recently been identified as a key, rate-limiting step in the disassembly process. Yet, the nature of the underlying molecular mechanism remains an outstanding question....

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Literature Corpus work: 69a1d33e-51a2-510b-99aa-658bd4a4385f
DOI: 10.1101/2023.05.24.542046

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