Article

Apolipoprotein A-I Mimetic 4F Peptide Generates Amyloid Cytotoxins by Forming Hetero-oligomers with β-amyloid

2019-08-04

Abstract excerpt

Apolipoproteins are involved in pathological conditions of Alzheimer’s disease (AD), truncated apolipoprotein fragments and β-amyloid (Aβ) peptides coexist as neurotoxic heteromers within the plaques. Therefore, it is important to investigate these complexes at the molecular level to better understand their properties and roles in the pathology of AD. Here, we present a mechanistic insight into such heteromerizati...

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Literature Corpus work: 71d58a50-b772-55e9-9f24-4c0f930b3efd
DOI: 10.1101/722983

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