Article

Ganglioside enriched phospholipid vesicles induce cooperative Aβ oligomerization and membrane disruption

2022-04-15

Abstract excerpt

<h4>ABSTRACT</h4> A major hallmark of Alzheimer disease (AD) is the accumulation of extracellular aggregates of amyloid-β (Aβ). Structural polymorphism observed among Aβ fibrils in AD brains seem to correlate with the clinical sub-types suggesting a link between fibril polymorphism and pathology. Since fibrils emerge from a templated growth of low-molecular weight oligomers, understanding the factors affecting ol...

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Literature Corpus work: 736895b7-1879-5e73-b39c-3bec168510ba
DOI: 10.1101/2022.04.14.488413

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