Article

Physical mechanisms of amyloid nucleation on fluid membranes

2019-12-27

Abstract excerpt

Biological membranes can dramatically accelerate the aggregation of normally soluble protein molecules into amyloid fibrils and alter the fibril morphologies, yet the molecular mechanisms through which this accelerated nucleation takes place are not yet understood. Here, we develop a coarse-grained model to systematically explore the effect that the structural properties of the lipid membrane and the nature of pro...

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Identifiers and source

Literature Corpus work: 46e74063-e6ce-5d30-ad8b-3efc77b10e2d
DOI: 10.1101/2019.12.22.886267

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